Bone marrow involvement in a patient with paracoccidioidomycosis: a rare presentation of juvenile form

Graziella Hanna Pereira; Aline Queiroz Santos; Miriam Park; Patricia Rady Muller; Soraia Padua; Raquel Ferrari Marchesi; Vera Lucia Aldred

doi:10.1007/s11046-010-9314-5

Bone marrow involvement in a patient with paracoccidioidomycosis: a rare presentation of juvenile form

Mycopathologia. 2010 Oct;170(4):259-61. doi: 10.1007/s11046-010-9314-5. Epub 2010 May 7.

Authors

Graziella Hanna Pereira¹, Aline Queiroz Santos, Miriam Park, Patricia Rady Muller, Soraia Padua, Raquel Ferrari Marchesi, Vera Lucia Aldred

Affiliation

¹ Department of Infectious Diseases and Infection Control, Brigadeiro Hospital, São Paulo, SP, Brazil. [email protected]

PMID: 20449771
DOI: 10.1007/s11046-010-9314-5

Abstract

Paracoccidioides brasiliensis rarely shows bone marrow involvement and its response to treatment with itraconazole in children needs further assessment. We describe here a child with a juvenile disseminated form of paracoccidioidomycosis, which showed reticuloendothelial system involvement and the presence of Paracoccidioides brasiliensis in the bone marrow. The patient showed an effective and rapid response to itraconazole therapy.

Publication types

Case Reports

MeSH terms

Antifungal Agents / therapeutic use
Biopsy
Bone Marrow / microbiology*
Bone Marrow / pathology
Child
Female
Histocytochemistry
Humans
Itraconazole / therapeutic use
Lymph Nodes / pathology
Microscopy
Osteomyelitis / diagnosis*
Osteomyelitis / drug therapy
Osteomyelitis / microbiology*
Osteomyelitis / pathology
Paracoccidioides / isolation & purification*
Paracoccidioidomycosis / complications*
Paracoccidioidomycosis / drug therapy
Treatment Outcome

Substances

Antifungal Agents
Itraconazole