Biofilms can evade antibiotics and immune attacks, and become liable to induce drug resistance, and correspondingly cause chronic and recalcitrant infection. traditional Chinese medicine show special advantages in treatment of biofilm infection. The author reviewed the reports concerning the research progress of traditional Chinese medicine in treating biofilms in light of its own research in recent years, and summarized the research progress on traditional Chinese medicine intervening biofilms of Pseudomonas aeruginosa, Staphylococcus, Escherichia coli and Candida albicans.