Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

Eur Psychiatry. 2010 Jun;25(5):268-71. doi: 10.1016/j.eurpsy.2010.01.009. Epub 2010 May 6.

Abstract

Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Depressive Disorder / genetics*
  • Depressive Disorder / psychology*
  • Epigenesis, Genetic
  • Humans
  • Stress, Psychological / genetics
  • Stress, Psychological / psychology*
  • Suicide / psychology*