Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes

Mirko Manchia; Clement C Zai; Alessio Squassina; John B Vincent; Vincenzo De Luca; James L Kennedy

doi:10.1016/j.euroneuro.2010.04.001

Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes

Eur Neuropsychopharmacol. 2010 Sep;20(9):663-70. doi: 10.1016/j.euroneuro.2010.04.001. Epub 2010 May 8.

Authors

Mirko Manchia¹, Clement C Zai, Alessio Squassina, John B Vincent, Vincenzo De Luca, James L Kennedy

Affiliation

¹ Laboratory of Molecular Genetics, Department of Neurosciences B.B. Brodie, University of Cagliari, Cagliari, Italy. [email protected]

PMID: 20452754
DOI: 10.1016/j.euroneuro.2010.04.001

Abstract

Bipolar Disorder (BPD) is a complex psychiatric disease with a relevant underlying genetic basis. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). 5-HTTLPR polymorphism associated with early onset component under recessive and additive model. HTR2A T102C, HTR2C Cys23Ser and 5-HTTLPR interaction terms associated with early onset component under dominant, recessive and additive model. These findings suggest a role of genes codifying for elements of the serotonergic system in influencing the AAO in BPD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age of Onset
Bipolar Disorder / epidemiology
Bipolar Disorder / genetics*
Female
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Receptor, Serotonin, 5-HT2A / genetics
Receptor, Serotonin, 5-HT2C / genetics
Regression Analysis
Serotonin Plasma Membrane Transport Proteins / genetics*

Substances

Receptor, Serotonin, 5-HT2A
Receptor, Serotonin, 5-HT2C
SLC6A4 protein, human
Serotonin Plasma Membrane Transport Proteins