Animal models of neurological disease

Adv Exp Med Biol. 2010:671:23-40. doi: 10.1007/978-1-4419-5819-8_3.

Abstract

The use of animal models to study human pathology has proved valuable in a number of fields. Animal models of neurological disease have successfully and accurately recreated many aspects of human illness allowing for in-depth study ofneuropathophysiology. These models have been the source of a plethora of information, such as the importance of certain molecular mechanisms and genetic contributions in neurological disease. Additionally, animal models have been utilized in the discovery and testing of possible therapeutic treatments. Although most neurological diseases are still not yet completely understood and reliable treatment is lacking, animal models provide a major step in the right direction.

Publication types

  • Review

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / pharmacology
  • Adrenergic Agents / pharmacology
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Antipsychotic Agents / pharmacology
  • Brain Ischemia / pathology
  • Brain Ischemia / physiopathology
  • Central Nervous System / drug effects
  • Central Nervous System / pathology
  • Central Nervous System / physiology
  • Central Nervous System / physiopathology
  • Central Nervous System Stimulants / pharmacology
  • Disease Models, Animal*
  • Humans
  • Methamphetamine / pharmacology
  • Nervous System Diseases* / pathology
  • Nervous System Diseases* / physiopathology
  • Neurotoxins / pharmacology
  • Oxidopamine / pharmacology
  • Reserpine / pharmacology
  • Rotenone / pharmacology
  • Uncoupling Agents / pharmacology

Substances

  • Adrenergic Agents
  • Amyloid beta-Protein Precursor
  • Antipsychotic Agents
  • Central Nervous System Stimulants
  • Neurotoxins
  • Uncoupling Agents
  • Rotenone
  • Methamphetamine
  • Reserpine
  • Oxidopamine
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine