A double-blind, randomized, placebo-controlled trial of intravenous L-ornithine-L-aspartate on postural control in patients with cirrhosis

Liver Int. 2010 Apr;30(4):574-82. doi: 10.1111/j.1478-3231.2010.02213.x.

Abstract

Introduction: Hepatic encephalopathy (HE) is a complication of liver disease. Several treatments have been introduced but only L-ornithine-L-aspartate (LOLA) shows proven efficacy. This double-blind, randomized, placebo-controlled trial evaluated the effect of LOLA on postural control in cirrhotics.

Methods: Forty patients were randomized to either LOLA or a placebo. HE was evaluated by psychometric testing (PSE Syndrome Test) and critical flicker frequency (CFF). Posturography [equilibrium score (ES)] provided information regarding postural control. Peripheral blood was analysed for ammonia concentration (NH(3)) and the partial pressure of ammonia (pNH(3)).

Results: Both groups were comparable regarding baseline variables. Posturography and PSE Syndrome Test improved in both groups; improvement was greater in the LOLA group (ES: 5.3%; PSE: 1.9) compared with the placebo (ES: 3.9%; PSE: 1.3) but did not reach significance (ES: P=0.3; PSE: P=0.5). CFF remained unchanged during treatment and between groups (P=NS). NH(3) decreased in the LOLA group (Delta: -15 micromol/L) and slightly increased in the placebo group (Delta: 11.1 micromol/L), but the differences did not reach statistical significance (P=0.07). pNH(3) remained largely unchanged (LOLA Delta: -1.2 x 10(-5) mmHg vs. placebo Delta: -0.3 x 10(-5) mmHg; P=0.21).

Conclusion: In the LOLA group, an improvement of posturographic control and PSE Syndrome Test was observed, but a similar improvement was also achieved by the placebo. In LOLA, ammonia levels tended to decrease while they tended to increase in the placebo group. LOLA might augment the improvement achieved by intravenous fluids alone but a larger cohort will be needed to show this effect with statistical significance.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Ammonia / blood
  • Biopsy, Needle
  • Dipeptides / administration & dosage*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Hepatic Encephalopathy / complications
  • Hepatic Encephalopathy / drug therapy
  • Hepatic Encephalopathy / mortality
  • Hepatic Encephalopathy / pathology
  • Hepatic Encephalopathy / psychology
  • Humans
  • Immunohistochemistry
  • Infusions, Intravenous
  • Liver Cirrhosis / complications*
  • Liver Cirrhosis / drug therapy*
  • Liver Cirrhosis / mortality
  • Liver Cirrhosis / pathology
  • Liver Function Tests
  • Male
  • Middle Aged
  • Pilot Projects
  • Postural Balance / drug effects*
  • Psychometrics
  • Reference Values
  • Risk Assessment
  • Sensation Disorders / drug therapy*
  • Sensation Disorders / etiology*
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Survival Rate
  • Treatment Outcome

Substances

  • Dipeptides
  • Ammonia
  • ornithylaspartate