Abstract
Synthesis of high-purity biogenic heterocyclic library enabled identification of a small molecule, which potently inhibited proliferation of several cancer cell lines and induces rapid oxidative stress. This agent elicited unusual mechanism of cell death induction, which entailed activation of both caspase-dependent and independent pathways.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Caspase 3 / metabolism
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Caspase 7 / metabolism
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Cell Line, Tumor
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High-Throughput Screening Assays
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Humans
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Oxidative Stress*
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Reactive Oxygen Species / metabolism
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Small Molecule Libraries / chemical synthesis*
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / pharmacology
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Structure-Activity Relationship
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Sulfonylurea Compounds / chemical synthesis
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Sulfonylurea Compounds / chemistry
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Sulfonylurea Compounds / pharmacology
Substances
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Reactive Oxygen Species
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Small Molecule Libraries
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Sulfonylurea Compounds
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tolcyclamide
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Caspase 3
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Caspase 7