Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

Antimicrob Agents Chemother. 2010 Jul;54(7):3056-7. doi: 10.1128/AAC.00597-10. Epub 2010 May 17.

Abstract

According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.

MeSH terms

  • Candida / drug effects*
  • Caspofungin
  • Drug Stability
  • Echinocandins / chemistry
  • Echinocandins / pharmacology*
  • Glucose / chemistry*
  • Lipopeptides
  • Microbial Sensitivity Tests

Substances

  • Echinocandins
  • Lipopeptides
  • Caspofungin
  • Glucose