Most muscle trauma more commonly involves the lower extremity, but injury to the chest wall, particularly the pectoralis major, is well recognized. Trauma to the upper limb muscle-tendon unit is preserved. Development of complications from muscle injury is also discussed. This article systematically reviews the clinical features, pathogenesis, imaging findings, and management for upper limb and chest wall muscle injuries. Imaging modalities focus on magnetic resonance imaging and ultrasound, highlighting their advantages and disadvantages in specific situations.