Highly oxygenated guaianolides from Artemisia dubia

Planta Med. 2010 Oct;76(15):1710-6. doi: 10.1055/s-0030-1249957. Epub 2010 May 19.

Abstract

Investigation of a Chinese folk medicine, Artemisia dubia (syn. Artemisia subdigitata), has resulted in the isolation of eight new guaianolides (artemdubolides A-H, 1-8), and nineteen known sesquiterpene lactones. Their structures were elucidated primarily on the basis of spectroscopic methods, including extensive 2D NMR experiments. The cytotoxic activities of compounds 1-8 were evaluated against A549 (human lung adenocarcinoma), Colo205 (human colon carcinoma), HepG2 (human hepatoma), and MDA-MB-435 (human melanoma) cell lines. Compounds 2 and 5 showed weak cell growth inhibition of Colo205 and MDA-MB-435 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Artemisia / chemistry*
  • Cell Line, Tumor
  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification
  • Cytotoxins / pharmacology*
  • Drugs, Chinese Herbal / chemistry*
  • Humans
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Sesquiterpenes, Guaiane / chemistry
  • Sesquiterpenes, Guaiane / isolation & purification
  • Sesquiterpenes, Guaiane / pharmacology

Substances

  • Cytotoxins
  • Drugs, Chinese Herbal
  • Sesquiterpenes
  • Sesquiterpenes, Guaiane