Abstract
A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkenes / chemistry*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Catalysis
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Cell Line, Tumor
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Humans
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Indoles / chemical synthesis*
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Indoles / chemistry*
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Indoles / pharmacology
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Inhibitory Concentration 50
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Palladium / chemistry*
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Stereoisomerism
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Substrate Specificity
Substances
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Alkenes
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Antineoplastic Agents
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Indoles
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Palladium