Assess the needs of Latino families with limited English proficiency (LEP) whose infant is discharged from the NICU. Parent interviews at discharge and 1 month later. Thirty-six mothers were interviewed. Thirty nine percentage had <8th grade education; half earned <$10,000 annually. Twenty-eight percentage had no primary support person inside the US. Only half felt very prepared for their infants' discharge. Many expressed general worry about their infant's medical condition (53%) and development (81%), but few (15%) could identify specific risk factors. One-third of families sought emergency medical care for their infant within 1 month of discharge. Less than half were aware of early intervention programs. Safe infant discharge from the NICU must address families' needs. Latino parents with LEP have deficits in knowledge about their infant's medical condition and available resources that place these vulnerable infants at further risk.