A randomised controlled trial of cognitive behaviour therapy for psychosis in a routine clinical service

Acta Psychiatr Scand. 2010 Oct;122(4):302-18. doi: 10.1111/j.1600-0447.2010.01572.x. Epub 2010 Jun 28.

Abstract

Objective: To evaluate cognitive behaviour therapy for psychosis (CBTp) delivered by non-expert therapists, using CBT relevant measures.

Method: Participants (N = 74) were randomised into immediate therapy or waiting list control groups. The therapy group was offered 6 months of therapy and followed up 3 months later. The waiting list group received therapy after waiting 9 months (becoming the delayed therapy group).

Results: Depression improved in the combined therapy group at both the end of therapy and follow-up. Other significant effects were found in only one of the two therapy groups (positive symptoms; cognitive flexibility; uncontrollability of thoughts) or one of the two time points (end of therapy: general symptoms, anxiety, suicidal ideation, social functioning, resistance to voices; follow-up: power beliefs about voices, negative symptoms). There was no difference in costs between the groups.

Conclusion: The only robust improvement was in depression. Nevertheless, there were further encouraging but modest improvements in both emotional and cognitive variables, in addition to psychotic symptoms.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antipsychotic Agents / therapeutic use
  • Anxiety
  • Cognitive Behavioral Therapy* / methods
  • Cognitive Behavioral Therapy* / organization & administration
  • Community Mental Health Services / organization & administration
  • Control Groups
  • Depression / etiology
  • Depression / therapy*
  • Humans
  • Middle Aged
  • Professional-Patient Relations
  • Psychiatric Status Rating Scales
  • Psychotic Disorders / complications
  • Psychotic Disorders / physiopathology
  • Psychotic Disorders / therapy*
  • Social Adjustment
  • Suicidal Ideation
  • Time Factors
  • Treatment Outcome
  • Young Adult

Substances

  • Antipsychotic Agents