This study examined the effects of a 24-week Tai Chi intervention on physical function in individuals with peripheral neuropathy. Twenty-five women and men with peripheral neuropathy were recruited. Plantar pressure detection threshold was assessed with a 5.07 gauge monofilament. Functional gait was assessed by the 6-min walk and timed up-and-go tests. Isokinetic leg strength and standing balance was also assessed. Twenty-four consecutive weeks of modified, group-based Tai Chi practice was completed, with testing repeated every six weeks throughout. No adverse events were observed and attendance was 17 +/- 4 sessions per 6 weeks. After 6 weeks of Tai Chi, participants increased 6-min walk (P < 0.0001), timed up-and-go (P < 0.0001), and leg strength (P < 0.01) performance. Continued improvement was observed in the timed up-and-go. Plantar sensation improved (P = 0.003) following the Tai Chi intervention. Group-based Tai Chi is a safe, plausible, and effective intervention for those with PN.