Abstract
Rong and colleagues have applied a mathematical model of hepatitis C virus (HCV) replication to experimental data from initial clinical investigations of HCV protease inhibitors. In this Perspective, we discuss how mathematical modeling and other modern translational research tools and approaches can be used to expedite drug development with well-designed combination clinical trials that test drugs from multiple collaborators.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Drug Design
-
Hepacivirus / drug effects
-
Hepacivirus / physiology*
-
Hepatitis C / drug therapy*
-
Humans
-
Models, Molecular
-
Protease Inhibitors / pharmacology
-
Protease Inhibitors / therapeutic use*
-
Viral Nonstructural Proteins / chemistry
-
Viral Nonstructural Proteins / metabolism
-
Virus Replication / drug effects
Substances
-
Protease Inhibitors
-
Viral Nonstructural Proteins