Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient

Emerg Infect Dis. 2010 Jun;16(6):1014-7. doi: 10.3201/eid1606.091671.

Abstract

Klebsiella pneumoniae carbapenemase (KPC) 3-producing Escherichia coli was isolated from a carrier of KPC-3-producing K. pneumoniae. The KPC-3 plasmid was identical in isolates of both species. The patient's gut flora contained a carbapenem-susceptible E. coli strain isogenic with the KPC-3-producing isolate, which suggests horizontal interspecies plasmid transfer.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Anti-Bacterial Agents / administration & dosage
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics*
  • Colistin / administration & dosage
  • Conjugation, Genetic*
  • Drug Resistance, Bacterial / genetics
  • Drug Therapy, Combination
  • Ertapenem
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Escherichia coli Infections / complications
  • Escherichia coli Infections / metabolism
  • Escherichia coli Infections / microbiology*
  • Gastrointestinal Tract / microbiology
  • Humans
  • Israel
  • Klebsiella Infections / complications
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics
  • Male
  • Metronidazole / administration & dosage
  • Plasmids / genetics*
  • Plasmids / metabolism
  • Vancomycin / administration & dosage
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / genetics*
  • beta-Lactams / administration & dosage

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-Lactams
  • Metronidazole
  • Vancomycin
  • beta-Lactamases
  • beta-lactamase KPC-3, Klebsiella pneumoniae
  • Ertapenem
  • Colistin