Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

Wei Shi; Yuejiao Duan; Yu Qian; Ming Li; Liping Yang; Wenhao Hu

doi:10.1016/j.bmcl.2010.04.123

Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3592-5. doi: 10.1016/j.bmcl.2010.04.123. Epub 2010 May 24.

Authors

Wei Shi¹, Yuejiao Duan, Yu Qian, Ming Li, Liping Yang, Wenhao Hu

Affiliation

¹ Department of Chemistry, East China Normal University, Shanghai, China.

PMID: 20510610
DOI: 10.1016/j.bmcl.2010.04.123

Abstract

The synthesis and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated, and some of these derivatives showed better in vitro antibacterial activity than existing drugs, including penicillin, ciprofloxacin, vancomycin, and linezolid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amidohydrolases / antagonists & inhibitors*
Amines / chemical synthesis*
Amines / pharmacology
Anti-Bacterial Agents / chemical synthesis*
Drug Design
Pyrroles / chemical synthesis*
Pyrroles / pharmacology
Structure-Activity Relationship

Substances

Amines
Anti-Bacterial Agents
Pyrroles
Amidohydrolases
peptide deformylase