Vitamin D in kidney disease: pathophysiology and the utility of treatment

Endocrinol Metab Clin North Am. 2010 Jun;39(2):355-63, table of contents. doi: 10.1016/j.ecl.2010.02.005.

Abstract

Vitamin D physiology has gained more importance and publicity than any of its counterparts in the water- and fat-soluble vitamin groups combined. This is partly because vitamin D deficiency is still widely prevalent in the developed world and the beneficial effects are thought to extend beyond the regulation of calcium and phosphorus homeostasis alone. Vitamin D deficiency becomes even more important in the various stages of chronic kidney disease (CKD); CKD itself is also on the increase. How vitamin D physiology is altered in CKD and how the various treatment modalities can alter the morbidity and mortality associated with CKD is the topic of discussion for this article.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / blood
  • Calcium / metabolism
  • Cardiovascular System / metabolism
  • Chronic Disease
  • Dietary Supplements
  • Fractures, Bone / drug therapy
  • Fractures, Bone / metabolism
  • Humans
  • Hyperparathyroidism, Secondary / drug therapy
  • Hyperparathyroidism, Secondary / metabolism
  • Hyperparathyroidism, Secondary / physiopathology
  • Hyperphosphatemia / drug therapy
  • Hyperphosphatemia / metabolism
  • Hyperphosphatemia / physiopathology
  • Kidney Diseases / complications*
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / metabolism
  • Mice
  • Phosphorus / metabolism
  • Vitamin D / metabolism*
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / drug therapy
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / etiology*

Substances

  • Vitamin D
  • Phosphorus
  • Calcium