Abstract
Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by S(N)Ar reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-elimination S(N)Ar mechanism was confirmed by NMR and MS measurements.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Aminobenzoic Acid / chemical synthesis*
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4-Aminobenzoic Acid / chemistry
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry
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Esterification
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Esters / chemical synthesis*
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Esters / chemistry
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Molecular Structure
Substances
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Amino Acids
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Esters
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4-Aminobenzoic Acid