Intra-arterial thrombolysis for central retinal artery occlusion: two cases report

J Korean Med Sci. 2010 Jun;25(6):974-9. doi: 10.3346/jkms.2010.25.6.974. Epub 2010 May 24.

Abstract

Central retinal artery occlusion (CRAO) causes severe visual loss in affected eye and vision does not recover in more than 90% of the patients. It is believed that it occurs by occlusion of the central retinal artery with small emboli from atherosclerotic plaque of internal cerebral artery. Retina is a part of the brain, thus basically CRAO is corresponding to acute occlusion of intracerebral artery and retinal ischemia is to cerebral stroke. Therefore, intra-arterial thrombolysis (IAT) has been considered as a treatment method in CRAO. Recently, we treated 2 patients diagnosed as CRAO and could achieve complete recanalization on fundus fluorescein angiogram with IAT. Of them, one recovered visual acuity to 20/25. We report our 2 CRAO cases treated with IAT and discuss technical aspects for IAT and management of patient. To the best of our knowledge, this is the first Korean report of IAT for CRAO.

Keywords: Central Retinal Artery Occlusion; Thrombolysis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Electroretinography
  • Fibrinolytic Agents / therapeutic use*
  • Fluorescein Angiography
  • Humans
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / therapeutic use
  • Retinal Artery Occlusion / diagnosis
  • Retinal Artery Occlusion / drug therapy*
  • Thrombolytic Therapy
  • Urokinase-Type Plasminogen Activator / therapeutic use*
  • Visual Acuity

Substances

  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors
  • Urokinase-Type Plasminogen Activator