Abstract
Four new bisindole alkaloids of the Strychnos-Strychnos type, leucoridines A-D (1-4), were isolated from the stem-bark extract of Leuconotis griffithii. Alkaloids 1-4 showed moderate cytotoxicity against drug-sensitive and vincristine-resistant human KB cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apocynaceae / chemistry*
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Drug Resistance, Neoplasm
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Drug Screening Assays, Antitumor
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Humans
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology*
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KB Cells
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Malaysia
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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Plants, Medicinal / chemistry*
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Strychnos / chemistry*
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Vincristine / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Indole Alkaloids
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Vincristine