Abstract
Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens.
MeSH terms
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Apoptosis / genetics
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Gene Expression Profiling / methods*
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Models, Genetic
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RNA Interference*
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RNA, Small Interfering / genetics
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RNA, Small Interfering / metabolism*
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TNF-Related Apoptosis-Inducing Ligand / genetics
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TNF-Related Apoptosis-Inducing Ligand / metabolism
Substances
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RNA, Small Interfering
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TNF-Related Apoptosis-Inducing Ligand