Rosuvastatin-induced thrombocytopenia

South Med J. 2010 Jul;103(7):676-8. doi: 10.1097/SMJ.0b013e3181e170f5.

Abstract

Rosuvastatin, a statin indicated for patients with primary hypercholesterolemia, mixed dyslipidemia and familial hypercholesterolemia, is well tolerated by most patients. Its most common adverse effects are gastrointestinal derangement, muscle aches and hepatitis. One rare complication of statin treatment is severe thrombocytopenia. The case of a 65-year-old patient who developed severe thrombocytopenia while on rosuvastatin is presented, in addition to a review of the literature.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Dyslipidemias / drug therapy
  • Female
  • Fluorobenzenes / adverse effects*
  • Fluorobenzenes / therapeutic use
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Pyrimidines / adverse effects*
  • Pyrimidines / therapeutic use
  • Rosuvastatin Calcium
  • Sulfonamides / adverse effects*
  • Sulfonamides / therapeutic use
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / diagnosis

Substances

  • Fluorobenzenes
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrimidines
  • Sulfonamides
  • Rosuvastatin Calcium