Signal-on electrochemiluminescence biosensor for thrombin based on target-induced conjunction of split aptamer fragments

Chem Commun (Camb). 2010 Aug 14;46(30):5563-5. doi: 10.1039/c0cc00932f. Epub 2010 Jun 7.

Abstract

A highly sensitive and selective electrochemiluminescence biosensor for detection of thrombin based on the strategy of target-induced conjunction of split aptamer fragments was developed.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aptamers, Nucleotide / chemistry
  • Aptamers, Nucleotide / metabolism*
  • Base Sequence
  • Biosensing Techniques / methods*
  • Electrochemistry / methods*
  • Humans
  • Luminescence
  • Nanoparticles / chemistry
  • Ruthenium / chemistry
  • Sensitivity and Specificity
  • Silicon Dioxide / chemistry
  • Thrombin / analysis*

Substances

  • Aptamers, Nucleotide
  • Silicon Dioxide
  • Ruthenium
  • Thrombin