Efficient construction of a 3C-xanthone-linked 3C-chromone scaffold by novel double Michael additions and cyclizations

Org Lett. 2010 Jul 2;12(13):3086-9. doi: 10.1021/ol101100d.

Abstract

A novel base-promoted cascade reaction of 2-methyl-3-(1-alkynyl)chromones to produce a 3C-xanthone-linked 3C-chromone scaffold has been developed. This tandem process involves multiple reactions such as Michael additions/cyclizations under mild conditions without a transition metal catalyst and inert atmosphere.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromones / chemical synthesis*
  • Chromones / chemistry*
  • Cyclization
  • Molecular Structure
  • Stereoisomerism

Substances

  • Chromones