Treatment of complex airway lesions after lung transplantation with self-expandable nitinol stents: early experience

Transplant Proc. 2010 May;42(4):1279-80. doi: 10.1016/j.transproceed.2010.03.092.

Abstract

Airway complications (AC) are considered a serious cause of morbidity after lung transplantation (LT). Mechanical dilatation, laser vaporization, and silicone stent placement usually solve it. However, the use of self-expandable metallic stents (SENS) may be indicated in selected cases. Ten lung transplant recipients with AC were treated with SENS. Six patients underwent LT for cystic fibrosis, 2 for idiopathic pulmonary fibrosis, 1 for bronchiectasis, and 1 for emphysema. All patients received at least 1 treatment attempt with dilatation and silicone stent placement. The indications for SENS placement were the presence of a tortuous airway axis with stenosis and malacia of the right main bronchus in 5 patients; a long stenosis of the main and intermediate right bronchus involving the upper lobe orifice in 3 patients; or malacia that could not be stabilized with silicone stents in 3 cases. In 1 patient the procedure was bilateral. Functional improvement was immediate with a mean forced expiratory volume at 1 second (FEV(1)) gain of 35%. No stent dislocation was observed. Symptoms did not occur again in 5 patients with previous recurrent episodes of pneumonia. One stenosis, which was due to the ingrowth of granulation tissue occurred at 6 months after the procedure, was successfully treated with mechanical dilatation and laser vaporization. The deployment of SENS in a selected group of patients with AC after LT was easy, safe, and effective.

MeSH terms

  • Alloys
  • Cystic Fibrosis / etiology
  • Cystic Fibrosis / surgery
  • Cystic Fibrosis / therapy
  • Dilatation / methods
  • Emphysema / etiology
  • Emphysema / surgery
  • Emphysema / therapy
  • Forced Expiratory Volume
  • Humans
  • Lung Transplantation / adverse effects*
  • Pulmonary Fibrosis / etiology
  • Pulmonary Fibrosis / surgery
  • Pulmonary Fibrosis / therapy
  • Silicones
  • Stents*
  • Treatment Outcome

Substances

  • Alloys
  • Silicones
  • nitinol