Introduction and hypothesis: Aims of this study were to compare the ultrasound measurement of bladder wall thickness (BWT) in women with different urodynamic diagnosis and to correlate BWT to the different urodynamic findings of detrusor overactivity (DO).
Methods: Two hundred forty seven women with urinary symptoms have been prospectively enrolled. Urodynamics and transvaginal ultrasound BWT were performed. Patients were divided into four urodynamic subgroups. BWT of women with DO was compared with the BWT of any other subgroup.
Results: Women with DO had a BWT value significantly higher (p < 0.0001). A cut-off of 6.5 mm for BWT had a positive predictive value of 100% for all DO. We use ROC curves to analyze the BWT for urgency urinary incontinence (AUC 0.645 95% CI 0.57-0.72) and the BWT for "pure DO" (AUC 0.702 95% CI 0.64-0.76) and for "all DO" (AUC 0.704 95% CI 0.64-0.77) vs other urodynamic diagnoses.
Conclusions: The ultrasound BWT showed a highly significant association with DO. However, the performance of this test cannot currently replace urodynamic testing.
Trial registration: ClinicalTrials.gov NCT01003457.