Pilomatrixoma, calcifying epithelioma of Malherbe, is a cutaneous tumor, originating from the hair matrix, mostly affecting pediatric population. We report a particularly uncommon location of pilomatrixoma: the scrotal skin. A 46-year-old man, without history, has developed a scrotal, multinodular firm tumor, measuring 10 cm. Most often, its preoperative diagnosis is not possible, because of its clinical polymorphism. The precise diagnosis is histological, by the revealing of mummified cells. The treatment is surgical, with only purpose to perform complete removal of pathologic tissue, allowing to decrease the rate of local relapse.
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