Abstract
The resistance rate of 67 Mycoplasma pneumoniae isolates from 356 ambulatory adult patients with respiratory tract infection was 69% (46 of 67). All 46 macrolide-resistant strains harbored point mutations in the 23S ribosomal RNA gene. Patients infected with macrolide-resistant M. pneumoniae required significantly longer durations of antibiotic therapy and had longer time to resolution of fever.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Child
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China
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial*
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Female
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Genes, rRNA / genetics
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Humans
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Macrolides / pharmacology*
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Macrolides / therapeutic use
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Male
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Middle Aged
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Molecular Sequence Data
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Mycoplasma pneumoniae / drug effects*
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Mycoplasma pneumoniae / isolation & purification
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Pneumonia, Mycoplasma / microbiology*
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Point Mutation
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RNA, Ribosomal, 23S / genetics
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Sequence Analysis, DNA
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Treatment Outcome
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Young Adult
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Macrolides
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RNA, Ribosomal, 23S
Associated data
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GENBANK/HM043729
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GENBANK/HM043730
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GENBANK/HM043731