T regulatory cells and transplantation tolerance

Transplant Rev (Orlando). 2010 Jul;24(3):147-59. doi: 10.1016/j.trre.2010.04.002. Epub 2010 Jun 11.

Abstract

Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation. The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunosuppressive Agents / pharmacology
  • T-Lymphocytes, Regulatory / immunology*
  • Transplantation Immunology
  • Transplantation Tolerance*
  • Transplantation, Homologous / immunology

Substances

  • Immunosuppressive Agents