Abstract
Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological*
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Escherichia coli / genetics*
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Escherichia coli / growth & development*
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Escherichia coli / metabolism
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Escherichia coli / physiology
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Escherichia coli Proteins / genetics*
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Escherichia coli Proteins / metabolism
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Evolution, Molecular*
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Gene Expression Regulation, Bacterial
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Genome, Bacterial*
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Glucose / metabolism*
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Glucose / pharmacology*
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Host Factor 1 Protein / genetics*
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Host Factor 1 Protein / metabolism
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Mutation*
Substances
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Escherichia coli Proteins
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Hfq protein, E coli
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Host Factor 1 Protein
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Glucose