Abstract
Three new phenolic glycosides, curculigosides F-H (1-3), were isolated from rhizomes of Curculigo orchioides Gaertn. Their structures were elucidated based on comprehensive spectroscopic analyses including IR, MS, 1D- and 2D NMR (HSQC, COSY, and HMBC). Curculigosides F-H (1-3) were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compound 1 exhibited weak activity with an IC(50) value of 2.08 mM on hepatitis B virus (HBV) e antigen (HBeAg) secretion of the HepG2.2.15 cell line.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Curculigo / chemistry*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Hep G2 Cells
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Hepatitis B e Antigens / metabolism*
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Hepatitis B virus / drug effects*
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Hepatitis B virus / metabolism
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Rhizome
Substances
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Antiviral Agents
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Glycosides
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Hepatitis B e Antigens
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Phenols
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Plant Extracts
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curculigoside F
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curculigoside G
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curculigoside H