Foreign citizens living in Italy with residence permit represent about 7,2% of the population even if the international migration started recently in the Country. Sanitary problems of children and families whose lifestyle and disease awareness strongly differ from the typical approach of the industrialized world are important also in the acceptance of the immuneprophylaxis. This aspect has to be taken in account when considering the integration of vaccination schedules. Public Health Services will be able to respond adequately to the health demand only identifying the need of foreign children and offering them the appropriate intervention.