Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450

J Biol Chem. 1978 May 10;253(9):3135-9.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Glands / drug effects
  • Adrenal Glands / metabolism*
  • Adrenocorticotropic Hormone / pharmacology*
  • Animals
  • Cholesterol / metabolism*
  • Cycloheximide / pharmacology*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Electron Spin Resonance Spectroscopy
  • Female
  • Kinetics
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Pregnenolone / biosynthesis*
  • Rats

Substances

  • Pregnenolone
  • Adrenocorticotropic Hormone
  • Cytochrome P-450 Enzyme System
  • Cholesterol
  • Cycloheximide