Abstract
Three patients are described with slowly progressive loss of speech and dysarthria associated with orofacial dyspraxia, initially with intact written language, who subsequently developed more widespread cognitive abnormalities. Positron emission tomography (PET) revealed bifrontal hypometabolism in all of the patients, most marked in the inferior and lateral portions of both frontal lobes, with some extension into the parietal and temporal cortices in one case. These patients may represent a further example of focal progressive cortical degeneration.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Apraxias / diagnosis
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Apraxias / physiopathology*
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Apraxias / psychology
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Brain Damage, Chronic / diagnosis
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Brain Damage, Chronic / physiopathology*
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Brain Damage, Chronic / psychology
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Dysarthria / diagnosis
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Dysarthria / physiopathology*
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Dysarthria / psychology
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Energy Metabolism / physiology*
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Female
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Frontal Lobe / physiopathology*
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Humans
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Intelligence / physiology
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Male
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Middle Aged
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Nerve Degeneration / physiology
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Neurocognitive Disorders / diagnosis
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Neurocognitive Disorders / physiopathology
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Neurocognitive Disorders / psychology
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Neuropsychological Tests
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Parietal Lobe / physiopathology
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Speech Production Measurement*
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Temporal Lobe / physiopathology
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Tomography, Emission-Computed
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Tomography, X-Ray Computed
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Verbal Behavior / physiology