A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis

Phytother Res. 2010 Sep;24(9):1414-6. doi: 10.1002/ptr.3154.

Abstract

A new protoberberine alkaloid, 3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxo-protoberberine, along with three known compounds, was isolated from Rhizoma Coptidis. The new compound displayed weak antispasmodic activity against acetylcholine-induced contraction in isolated guinea-pig ileum with an IC50 of 83.7 microm.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine
  • Animals
  • Berberine Alkaloids / isolation & purification
  • Berberine Alkaloids / pharmacology*
  • Coptis / chemistry*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / pharmacology*
  • Guinea Pigs
  • Ileum / drug effects*
  • Inhibitory Concentration 50
  • Male
  • Muscle Contraction / drug effects*
  • Muscle, Smooth / drug effects*
  • Parasympatholytics / isolation & purification
  • Parasympatholytics / pharmacology*
  • Rhizome

Substances

  • 3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxoprotoberberine
  • Berberine Alkaloids
  • Drugs, Chinese Herbal
  • Parasympatholytics
  • Acetylcholine