Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity

ChemMedChem. 2010 Aug 2;5(8):1242-6. doi: 10.1002/cmdc.201000165.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / chemical synthesis
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / therapeutic use
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / therapeutic use
  • Binding Sites
  • Cell Line, Tumor
  • Computer Simulation
  • Cyclooxygenase 1 / chemistry
  • Cyclooxygenase 1 / metabolism
  • Cyclooxygenase 2 / chemistry
  • Cyclooxygenase 2 / metabolism
  • Cyclooxygenase 2 Inhibitors / chemical synthesis
  • Cyclooxygenase 2 Inhibitors / chemistry
  • Cyclooxygenase 2 Inhibitors / therapeutic use
  • Cyclooxygenase Inhibitors / chemical synthesis
  • Cyclooxygenase Inhibitors / chemistry
  • Cyclooxygenase Inhibitors / therapeutic use
  • Humans
  • Neoplasms / drug therapy*
  • Pyrazoles / chemical synthesis
  • Pyrazoles / chemistry*
  • Pyrazoles / therapeutic use
  • Pyridines / chemical synthesis
  • Pyridines / chemistry*
  • Pyridines / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Pyrazoles
  • Pyridines
  • pyrazolopyridine
  • Cyclooxygenase 1
  • Cyclooxygenase 2