Synthesis of polyhalo acridones as pH-sensitive fluorescence probes

Chao Huang; Sheng-Jiao Yan; Yan-Mei Li; Rong Huang; Jun Lin

doi:10.1016/j.bmcl.2010.05.101

Synthesis of polyhalo acridones as pH-sensitive fluorescence probes

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4665-9. doi: 10.1016/j.bmcl.2010.05.101. Epub 2010 Jun 2.

Authors

Chao Huang¹, Sheng-Jiao Yan, Yan-Mei Li, Rong Huang, Jun Lin

Affiliation

¹ Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.

PMID: 20573505
DOI: 10.1016/j.bmcl.2010.05.101

Abstract

Polyhalo isophthalonitriles were reacted with substituted anilines and subsequently cyclocondensed in the presence of sulfuric acid to give polyhalo acridones. These polyhalo acridones were proven to be useful as pH-sensitive fluorescent probes for a wide range of acidic and basic conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acridones / chemical synthesis
Acridones / chemistry*
Acridones / toxicity
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / toxicity
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fluorescent Dyes / chemical synthesis*
Fluorescent Dyes / chemistry
Fluorescent Dyes / toxicity
Humans
Hydrogen-Ion Concentration
Spectrophotometry, Ultraviolet
Sulfuric Acids / chemistry

Substances

Acridones
Antineoplastic Agents
Fluorescent Dyes
Sulfuric Acids
sulfuric acid