Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Am J Med Genet B Neuropsychiatr Genet. 2010 Oct 5;153B(7):1347-9. doi: 10.1002/ajmg.b.31108.

Abstract

We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bipolar Disorder / genetics*
  • Case-Control Studies
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Polymorphism, Genetic*
  • Receptors, GABA-A / genetics*
  • Schizophrenia / genetics*

Substances

  • GABRR1 protein, human
  • Receptors, GABA-A