Abstract
Three new bromotyrosine alkaloids, ceratinadins A-C (1-3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Animals
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Imidazoles / chemistry*
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Imidazoles / isolation & purification
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Imidazoles / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Porifera / chemistry*
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Quinolines / chemistry*
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Quinolines / isolation & purification
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Quinolines / pharmacology
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Tyrosine / analogs & derivatives*
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Tyrosine / chemistry
Substances
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Alkaloids
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Antifungal Agents
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Imidazoles
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Quinolines
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bromotyrosine
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ceratinadin A
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ceratinadin B
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ceratinadin C
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Tyrosine