Mifepristone (RU486), a pure antiprogesterone drug, in combination with vinblastine for the treatment of progesterone receptor-positive desmoid tumor

Tech Coloproctol. 2010 Sep;14(3):265-7. doi: 10.1007/s10151-010-0591-2. Epub 2010 Jun 29.

Abstract

We report the case of a patient who developed a desmoid tumor following total proctocolectomy and J-pouch reconstruction that was unresponsive to any medical treatment. Based on estrogen receptor alpha (ERalpha) and progesterone receptor (PR) evaluation (ERalpha-negative, but PR-positive), treatment with mifepristone, a pure antiprogesterone drug, was initiated, and partial tumor regression was achieved.

Publication types

  • Case Reports

MeSH terms

  • Adenomatous Polyposis Coli / diagnosis
  • Adenomatous Polyposis Coli / surgery*
  • Adult
  • Anastomosis, Surgical / methods
  • Desmoid Tumors / diagnosis
  • Desmoid Tumors / drug therapy*
  • Disease Progression
  • Drug Therapy, Combination
  • Fatal Outcome
  • Humans
  • Imaging, Three-Dimensional
  • Male
  • Mifepristone / therapeutic use*
  • Peritoneal Neoplasms / diagnostic imaging
  • Peritoneal Neoplasms / drug therapy*
  • Peritoneal Neoplasms / secondary
  • Proctocolectomy, Restorative / methods
  • Receptors, Progesterone / metabolism
  • Tomography, X-Ray Computed
  • Vinblastine / therapeutic use*

Substances

  • Receptors, Progesterone
  • Mifepristone
  • Vinblastine