Background and aims: Thickening and abnormal architecture of the esophageal wall in gastroesophageal reflux disease (GERD) have been reported using endoscopic ultrasonography (US), but whether extracorporeal abdominal US is a useful diagnostic modality has not been investigated.
Methods: Subjects were 37 GERD, 24 non-erosive reflux disease (NERD) patients and 32 controls who visited our hospital from 2006-2009 and underwent upper gastrointestinal endoscopy and extracorporeal abdominal US. The US operator was unaware of any clinical information and examined the following: (i) thickness (>or=5 mm) and (ii) architecture of the esophageal wall; and (iii) presence of reflux. GERD was diagnosed when two or more of these items were positive.
Results: Thickening of the lower esophageal wall in erosive GERD, NERD and controls was 5.7 +/- 0.6, 4.4 +/- 0.8 and 4.7 +/- 0.9 mm, respectively. The thickness in erosive GERD was significantly greater (P < 0.05) than that in NERD patients and controls. Sensitivity, specificity and accuracy of abdominal US diagnosis for erosive GERD and NERD (vs control) was 84.6% (11/13), 25% (6/24), 91.1% (31/34) and 91.1% (31/34), 89.4% (42/47) and 63.8% (37/58), respectively.
Conclusion: Extracorporeal abdominal US could be a new useful modality for diagnosing GERD.