Abstract
Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus-based vaccine is administered 20-30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Macaca mulatta
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Marburg Virus Disease / prevention & control*
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Marburgvirus / immunology*
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Monkey Diseases / prevention & control*
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Vaccines, Synthetic / immunology
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Vesicular stomatitis Indiana virus / genetics
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Viral Vaccines / immunology*
Substances
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Vaccines, Synthetic
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Viral Vaccines