Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists

ChemMedChem. 2010 Sep 3;5(9):1450-5. doi: 10.1002/cmdc.201000185.

Affiliation

¹ Neurosciences Center of Excellence for Drug Discovery, GlaxoSmithKline Medicines Research Center, Via A. Fleming 4, 37135 Verona, Italy. [email protected]

PMID: 20593439
DOI: 10.1002/cmdc.201000185

No abstract available

MeSH terms

Cell Line
Drug Evaluation, Preclinical
Feeding and Eating Disorders / drug therapy
Humans
Hydrazines / chemical synthesis
Hydrazines / chemistry*
Hydrazines / therapeutic use
Receptors, Ghrelin / antagonists & inhibitors*
Receptors, Ghrelin / metabolism
Structure-Activity Relationship

Substances

Hydrazines
Receptors, Ghrelin
carbohydrazide