Abstract
Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors.
Copyright 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Catalytic Domain
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Cathepsin K / antagonists & inhibitors
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Cathepsin K / metabolism
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Cathepsins / antagonists & inhibitors*
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Cathepsins / metabolism
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Cell Line
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Computer Simulation
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Humans
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Nitriles / chemical synthesis
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Nitriles / chemistry*
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Nitriles / pharmacology
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Protease Inhibitors / chemical synthesis
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Protease Inhibitors / chemistry*
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Protease Inhibitors / pharmacology
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Purines / chemical synthesis
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Purines / chemistry*
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Purines / pharmacology
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Pyrimidines / chemistry
Substances
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2-phenyl-9H-purine-6-carbonitrile
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Nitriles
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Protease Inhibitors
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Purines
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Pyrimidines
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Cathepsins
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cathepsin S
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Cathepsin K
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pyrimidine