Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study

Ke Wang; Zhan-Zhu Liu

doi:10.1016/j.ejmech.2010.06.009

Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study

Eur J Med Chem. 2010 Sep;45(9):4175-9. doi: 10.1016/j.ejmech.2010.06.009. Epub 2010 Jun 12.

Authors

Ke Wang¹, Zhan-Zhu Liu

Affiliation

¹ Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.

PMID: 20598779
DOI: 10.1016/j.ejmech.2010.06.009

Abstract

A novel series of N-methylbisindolylmaleimides derivatives bearing 2-acetamino acid moieties were synthesized. The cytotoxic activities of these compounds were tested in six tumor cell lines. The most potent compound 8d displayed cytotoxicity against six human tumor cell lines in the micromolar range.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry*
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Design
Esters
Humans
Indoles / chemical synthesis*
Indoles / chemistry
Indoles / pharmacology*
Inhibitory Concentration 50
Maleimides / chemical synthesis*
Maleimides / chemistry
Maleimides / pharmacology*

Substances

Amino Acids
Antineoplastic Agents
Esters
Indoles
Maleimides
bisindolylmaleimide