Petiolins J-M, prenylated acylphloroglucinols from Hypericum pseudopetiolatum var. kiusianum

Naonobu Tanaka; Mio Otani; Yoshiki Kashiwada; Yoshihisa Takaishi; Azusa Shibazaki; Tohru Gonoi; Motoo Shiro; Jun'ichi Kobayashi

doi:10.1016/j.bmcl.2010.06.047

Petiolins J-M, prenylated acylphloroglucinols from Hypericum pseudopetiolatum var. kiusianum

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4451-5. doi: 10.1016/j.bmcl.2010.06.047. Epub 2010 Jun 12.

Authors

Naonobu Tanaka¹, Mio Otani, Yoshiki Kashiwada, Yoshihisa Takaishi, Azusa Shibazaki, Tohru Gonoi, Motoo Shiro, Jun'ichi Kobayashi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 20598881
DOI: 10.1016/j.bmcl.2010.06.047

Abstract

Four new prenylated acylphloroglucinols, petiolins J-M (1-4), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum, and the structures were elucidated by spectroscopic data and a single-crystal X-ray diffraction analysis. Petiolin J (1) exhibited antimicrobial activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / toxicity
Cell Line
Crystallography, X-Ray
Humans
Hypericum / chemistry*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Conformation
Phloroglucinol / analogs & derivatives*
Phloroglucinol / chemistry*
Phloroglucinol / isolation & purification
Phloroglucinol / toxicity
Prenylation

Substances

Anti-Bacterial Agents
petiolin J
Phloroglucinol