Two new amide alkaloids from the flower of Datura metel L

Fitoterapia. 2010 Dec;81(8):1003-5. doi: 10.1016/j.fitote.2010.06.017. Epub 2010 Jun 28.

Abstract

Two new amide alkaloids were isolated from the alkaloidal fraction of Datura metel L. Their structures were elucidated as (E)-methyl 4-(3-(4-hydroxyphenyl)-N-methylacrylamido) butanoate and 6,7-dimethyl-1-D-ribityl-quinoxaline-2,3(1H,4H)-dione-5'-O-β-D-glucopyranoside on the basis of spectroscopic methods including HRESIMS, 1D and 2D NMR. Tropane alkaloids have for a long time been considered as characteristic ingredients of D. metel. However, the presence of amide alkaloids in D. metel was reported for the first time in this study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry*
  • Alkaloids / chemistry*
  • Butyrates / chemistry*
  • Datura metel / chemistry*
  • Flowers / chemistry*
  • Glucosides / chemistry*
  • Molecular Structure
  • Quinoxalines / chemistry*

Substances

  • (E)-methyl 4-(3-(4-hydroxyphenyl)-N-methylacrylamido) butanoate
  • 6,7-dimethyl-1-D-ribityl-quinoxaline-2,3(1H,4H)-dione-5'-O-beta-D-glucopyranoside
  • Acrylamides
  • Alkaloids
  • Butyrates
  • Glucosides
  • Quinoxalines