Kallikrein-kinin system: a surgical perspective in post-aprotinin era

Pankaj Saxena; Philip Thompson; Yves d'Udekem; Igor E Konstantinov

doi:10.1016/j.jss.2009.12.020

Kallikrein-kinin system: a surgical perspective in post-aprotinin era

J Surg Res. 2011 May 1;167(1):70-7. doi: 10.1016/j.jss.2009.12.020. Epub 2010 Jan 15.

Authors

Pankaj Saxena¹, Philip Thompson, Yves d'Udekem, Igor E Konstantinov

Affiliation

¹ School of Surgery, University of Western Australia, Perth, Australia.

PMID: 20605589
DOI: 10.1016/j.jss.2009.12.020

Abstract

Kallikrein-kinin system (KKS) plays an important role in inflammation, ischemia-reperfusion (IR) injury, and development of neoplasia. There is evidence to suggest that KKS plays an important role in organ protection during preconditioning. Aprotinin is a nonspecific serine protease inhibitor, which has been extensively used in cardiac surgery for the control of post operative bleeding. The anti-inflammatory effects of aproprotin are due to its inhibitory effect on the kallikrein-kinin system (KKS). We herein review KKS and its role as applied to the practice of surgery.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aprotinin / pharmacology*
Humans
Ischemic Preconditioning, Myocardial
Kallikrein-Kinin System / drug effects*
Kallikrein-Kinin System / physiology
Myocardial Reperfusion Injury / physiopathology
Neoplasms / physiopathology
Postoperative Hemorrhage / prevention & control*

Substances

Aprotinin