Abstract
In a cohort study of children < 4 years of age in Greenland, mannose-binding lectin (MBL2) genotypes and Epstein-Barr virus (EBV) antibody levels were determined. EBV seropositivity was significantly lower and time to seroconversion increased in MBL-insufficient compared with MBL-sufficient children, indicating that MBL may be involved in primary EBV infection in infancy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Viral / blood
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Child
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Child, Preschool
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Disease Susceptibility*
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Epstein-Barr Virus Infections / genetics*
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Epstein-Barr Virus Infections / immunology*
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Female
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Genotype
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Greenland
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Herpesvirus 4, Human / immunology*
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Herpesvirus 4, Human / pathogenicity*
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Humans
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Infant
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Male
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Mannose-Binding Lectin / deficiency*
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Mannose-Binding Lectin / genetics
Substances
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Antibodies, Viral
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MBL2 protein, human
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Mannose-Binding Lectin